Publications

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Gábor Somlyai, T. Que Collins, Emmanuelle J. Meuillet, Patel Hitendra, Dominic P. D’AgostinoLászló G. Boros (2017) Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma. Oncotarget Download

László G. Boros, T. Que Collins, Gábor Somlyai (2017) What to eat or what not to eat–that is still the question. Neuro-Oncology XX(XX), 1–2, 2017 (DOI: 10.1093/neuonc/now284) Download

G. Somlyai, B. Javaheri, H. Davari, Z. Gyöngyi, I. Somlyai, K.A. Tamaddon, L.G. Boros (2016) Pre-Clinical and Clinical Data Confirm the Anticancer Effect of Deuterium Depletion. Biomacromol. J., Vol. 2, No. 1, 1-7, June 2016.  Download

László G. Boros, Gábor Somlyai, T. Que Collins, Hitendra Patel, Richard D. Beger (2016) Serine Oxidation via Glycine Cleavage (SOGC) Continues its Emergence as a Hallmark of Defective Mitochondria. Cell Metabolism, 23:635-648. Download

 

László G. Boros, Dominic P. D'Agostino, Howard E. Katz, Justin P. Roth, Emmanuelle J. Meuillet, Gábor Somlyai (2016) Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Medical Hypotheses, 87, 69-74 (DOI: http://dx.doi.org/10.1016/j.mehy.2015.11.016) Download

 

László G. Boros, Gábor Somlyai (2105) Deuterium and Hydrogen Ratios Determine Proton Spin-Lattice T1-Weighted Magnetic Resonance Images: Clinical Applications in Cancer. ESIR Isotope Workshop XIII, Zadar, 2015 DOI: 10.13140/RG.2.1.2592.0487 Download


László G. Boros, Richard D. Beger, Emmanuelle J. Meuillet, Jerry R. Colca, Sándor Szalma, Patricia A. Thompson, László Dux, Gyula Farkas Jr., and Gábor Somlyai (2015) Targeted 13C-Labeled Tracer Fate Associations for Drug Efficacy Testing in Cancer In book: Tumor Cell Metabolism - Pathways, Regulation and Biology, Edition: First, Chapter: On the New Omics of Metabolism, Publisher: Springer Vienna, Editors: Sybille Mazurek, Maria Shoshan, pp.349-372 DOI: 10.1007/978-3-7091-1824-5_15 

 

L.G. Boros, E.J. Meuillet, I. Somlyai, G. Jancsó, G. Jákli, K. Krempels, L.G. Puskás, L. Nagy, M. Molnár, K.R. Laderoute, P.A. Thompson, G. Somlyai (2014) Fumarate hydratase and deuterium depletion control oncogenesis via NADPH-dependent reductive synthesis. AACR 2014 - Annual Meeting, April 5-9, San Diego, CA, USA Download

 

G. Somlyai, M. Molnár, I. Somlyai, I. Fórizs, Gy. Czuppon, K. Balog, O. Abonyi, K. Krempels (2014) Effect of subnormal level of deuterium on glucose tolerance, serum HDL- and Na+-concentration. Egészségtudomány /Health Science, 58/1, 104-123 Download

 

K. Krempels, I. Somlyai, Z. Gyöngyi, I. Ember, K. Balog, O. Abonyi, G. Somlyai (2013)  A retrospective study of survival in breast cancer patients undergoing deuterium depletion in addition to conventional therapies. Journal of Cancer Research & Therapy 2013, 1(8):194–200 Download

 

Z. Gyöngyi, F. Budán, I. Szabó, I. Ember, I. Kiss, K. Krempels, I. Somlyai, G. Somlyai (2012) Deuterium Depleted Water Effects on Survival of Lung Cancer Patients and Expression of Kras, Bcl2 and Myc Genes in Mouse Lung. Nutrition and Cancer, 65:2, 240-246. Download

 

D. S. Ávila, G. Somlyai, I. Somlyai, M. Aschner (2012) Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model, Toxicology Letters Jun 20; 211(3):319-24. Epub 2012 Apr 26 . Download

 

A. Kovács, I. Guller, K. Krempels, I. Somlyai, I. Jánosi, Z. Gyöngyi, I. Szabó, I. Ember and Gábor Somlyai (2011) Deuterium Depletion May Delay the Progression of Prostate Cancer. Journal of Cancer Therapy 2, 548-556. Download 

 

Somlyai G., Molnár M., Laskay G., Szabó M., Berkényi T., Guller I., Kovács A. (2010) A természetben megtalálható deutérium biológiai jelentősége: a deutériumdepletio daganatellenes hatása/Biological significance of naturally occuring deuterium: the antitumor effect of deuterium depletion. Orvosi Hetilap 151(36):1455-1460. Download

 

G. Somlyai, A. Kovács, I. Guller, Z. Gyöngyi, K. Krempels, I. Somlyai, M. Szabó, T. Berkényi, M. Molnár (2010) Deuterium has a key role in tumour development – new target in anticancer drug development. European Journal of Cancer 8(5):208. Download

 

Molnár, M., Horváth, K., Dankó, T., et al (2010).: Effect of deuterium oxide (D2O) content of drinking water on glucose metabolism on STZ-induced diabetic rats. Proceedings of the 7th International Conference Functional Foods in the Prevention and Management of Metabolic Syndrome. 154-155. Download

 

Krisztina Krempels, Ildikó Somlyai and Gábor Somlyai (2008) A retrospective evaluation of the effects of deuterium depleted water consumption on four patients with brain metastases from lung cancer. Integrative Cancer Therapies 7(3):172-81. Download

 

Somlyai, G. (2007) A hidrogén/deutérium izotóppár biológiai jelentősége – a deutériumdepléció daganatellenes hatása/ Deuterium, as a key element in cell growth regulation. Biokémia, 31: 28-32. Download

 

Laszlo G. Boros, Andrei Kochegarov, Istvan Szigeti, Samuel T. Lee, Gabor Jancso, Gyorgy Jakli and Gabor Somlyai (2006): Deuterium depleted water alters glucose-derived fatty acid and cholesterol synthesis of tumor cells. The Second Scientific Meeting of the Metabolomics Society, 87. Download, poster

 

Györe I., Somlyai G. (2005) Csökkentett deutérium tartalmú ivóvíz hatása a teljesítőképességre sportolóknál/ The effect of deuterium depleted drinking water on the performance of sportsmen. Sportorvosi Szemle/Hungarian Review of Sports Medicine 46/1:27-38 Download

 

Somlyai, G. (2005) A deutérium depletio elvének alkalmazása a daganatterápiában és a megelőzésben. Látlelet, XLIX(10):8

 

Somlyai, G. (2004) A deutérium depletio hatása IV. stádiumban lévő, emlőtumoros betegek várható túlélésére/Deuterium Depletion and its Impact on Life Expectancy of Patients with Stage IV breast tumor. Komplementer Medicina/Journal of Complementary and Alternative Medicine VIII (4):30-35. Download

 

Szabó M., Sápi Z., Berkényi T., Somlyai G. (2003) A deutérium-megvonás hatása állati tumorokra és azok pathológiás képére [The Effect of Deuterium Depletion on Animal Tumors and their Pathological Pattern]. Az állatorvos  III (7-8):22-23, 26-27.

 

G. Somlyai (2001) A deutérium depletio prosztatatumorokra gyakorolt hatása – A Fázis II. klinikai vizsgálat interim értékelése/The Effect of Deuterium Depletion on tumors of the Prostate Interim Evaluation of a Phase 2 Clinical Trial. Komplementer Medicina/Journal of Complementary and Alternative Medicine V(4):28-31. Download

 

Laskay, G., Somlyai, G., Jancsó, G., Jákli, Gy. (2001) Reduced deuterium concentration of water stimulates O2-uptake and electrogenic H+-efflux in the aquatic macrophyte Elodea Canadensis Journal of Deuterium Sciences 10, 17-23 (2001) Download

 

G. Somlyai, G. Jancsó, Gy. Jákli, T. Berkényi, Z. Gyöngyi, I. Ember (2001) The Biological Effect of Deuterium Depleted Water, a Possible New Tool in Cancer Therapy. Anticancer Research 21:1617. Download

 

Berkényi T., Szabó M., Jákli Gy., Jancsó G., Somlyai G. (2000) A deutérium depléció elvének alkalmazása a daganatterápiában [The application of Dd-water in veterinary practice]. KisállatPraxis 2000/4, 1, 4:24-28. Download

 

Z. Gyöngyi, G. Somlyai (2000) Deuterium Depletion can Decrease the Expression of c-myc, Ha-Ras and p53 Gene in Carcinogen-Treated Mice. In vivo 14:437-440. Download

 

G. Somlyai, G. Laskay, T. Berkényi, Z. Galbács, G. Galbács, S.A. Kiss, Gy. Jákli, G. Jancsó (1998) The Biological Effects of Deuterium-Depleted Water, a Possible New Tool in Cancer Therapy. Z. Onkol. /J. of Oncol. 30, 4. Download

 

Gábor Somlyai (1998) Csökkentett deutérium-tartalmú víz, Új lehetőség a daganatterápiában [Deuterium depleted water – A new possibility in cancer therapy] Komplementer Medicina / Journal of Complementary Medicine II. évf. 6.szám, 6-9.

 

Gábor Somlyai, G. Laskay, T. Berkényi, Gy. Jákli, G. Jancsó (1998) Naturally occuring deuterium may have a central role in cell signalling. Synthesis and Application of Isotopically Labelled Compounds 1997. Edited by J.R. Heys and D.G. Mellilo © 1998 John Wiley & Sons Ltd. Download

 

G. Somlyai (1997) Biologische Auswirkungen von Wasser mit vermindertem Deuterium gehalt. Acta medica empirica, 7/1997, 381-388.

 

Berkényi Tamás, Somlyai Gábor, Jákli György, Jancsó Gábor (1996) Csökkentett deutérium-tartalmú (Dd-víz) alkalmazása az állatgyógyászatban. Kisállatorvoslás, 1996/3, 114-115.

 

Gábor Somlyai, Gábor Jancsó, György Jákli, Kornélia Vass, Balázs Barna, Viktor Lakics and Tamás Gaál (1993) Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Lett. 317, 1-4. Download